Ambrox

Conformational Analysis The "Ambergris Triangle" which is also known as know as the "Triaxial Rule" is illustrated by the images of ambrox, which are on the left and below. In order to smell like ambergris, synthetic analogs must have two axial hydrogens within 2.38 Angstroms +/-0.35 Å of each other eg. (III), and one axial hydrogen must be within 2.90 Angstroms +/-0.40 Å of an oxygen atom in an adjacent ring, eg. (I) with the other axial hydrogen 2.45 Angstroms +/-0.35 Å from the oxygen atom, eg. (II). Ambrox meets these criteria as illustrated in the examples.

Define the distances (Å) in the spatial triangle for a synthetic compound, Analog A, in the jmol model below the ambrox images. Determine if it will smell like ambergris or not based on the Triaxial Rule. Be sure to clearly illustrate the triangle and appropriate interatomic distances to support your conclusion.
[Note: The ring system of the Analog is slightly different than ambrox, but the Triaxial Rule still applies.]

After completing your analysis for Analog A, if you have not already done so repeat the process for Analog B.

(I)

(II)

(III)

Analog A: